Posts Tagged ‘Types Of Leukemia’



Leukemia interferes with the body’s production of white blood cells. These cells are supposed to fight infections with viruses or bacteria, and when someone has leukemia, they are defective and their number is largely increased, but because they are not fulfilling their role any more, although their number can increase ten times the body’s defense system is seriously weakened and any infection can be very dangerous.

Unfortunately leukemia can affect young children too, and the number of child leukemia cases keeps increasing.
There are two types of leukemia – acute leukemia – a cancer that develops and evolves very fast and it affects all the white blood cells, and chronic leukemia – it develops slower and healthy white blood cells can still be found.

More than 95% of the child leukemia cases are acute leukemia. Acute leukemia can also be divided into acute acute myelogenous leukemia and lymphocytic leukemia acute myelogenous leukemia because there are two types of blood cells, and each type of leukemia affects a different kind of blood cells. More than half of the children with leukemia have acute lymphocytic leukemia.

The symptoms of acute leukemia start with fever, and continue with many infections, because the child is weak against any damaging foreign microorganisms.
When the disease advances the child becomes anemic and begins to have a pale color. He will always feel a sensation of weakness and fatigue which will prevent him from playing outdoors.
All leukemia patients, including children can be bruised very easy, and the often bleed for no reason. When bleeding occurs it cannot be stopped for a long time because leukemia affects the cells responsible for healing wounds.

If the illness is not discovered and it is left untreated it starts spreading through the body and it can reach the brain, affecting some of the senses and causing headaches.

In order to diagnose child leukemia the child must go through a series of special tests. If the result is positive then therapy must begin as soon as possible. First some new tests must be performed to determine what kind of therapy works best. In most cases chemotherapy is used because it has the highest survival rate. Chemotherapy is also accompanied by drugs.
The purpose of the therapy is to heal the bone marrow, the organ that produces the defective blood cells and to kill all the malfunctioning cells from the body. If the therapy is successful it must still be continued because the cancer can re-appear.
In some more severe cases a bone marrow transplant is needed.

The good news is that therapy is getting better and better and most of the children survive this illness, but the survival rate depends on how far the cancer has advanced and on what form of it the child has.

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The actual causes of leukemia are still unknown to medical science. Although there are many speculations upon this matter, scientists haven’t yet found any conclusive evidence regarding the exact causes and risk factors of leukemia. However, medical science has made great progresses in identifying various genetic particularities that are nowadays considered to be underlying causes of leukemia. It seems that each type of leukemia is caused by a specific set of genetic dysfunctions which triggers an overproduction of diseased cells. Thanks to the ongoing efforts of medical scientists focused towards unveiling the factors involved in causing the occurrence and the development of leukemia, modern medicine may soon come up with an effective cure for this type of cancer.

Scientists have recently revealed a connection between T-cell acute lymphatic leukemia (T-ALL) and ABL1 gene. ABL1 resides in chromosome 9. Due to genetic dysfunctions, a fragment of DNA that contains ABL1 fuses with another gene, thus causing T-ALL. ABL1 gene is also known to have a role in the occurrence of various other types of leukemia. Oncologists explain that the abnormal activity of ABL1 cancer gene can be countered with the means of already-existent leukemia medications such as Glivec. Thus, Glivec may also be effective in overcoming the cases of T-ALL that are caused by the malfunctioning ABL1 gene.

Inappropriate activity of ABL1 gene is known to be the underlying cause of more than 6 percent of all T-ALL cases. ABL1 is in fact a type of protein that regulates various cellular processes. Impaired activity of ABL1 determines a wide range of cellular dysfunctions. In the case of T-ALL, ABL1 is responsible for causing an overproduction of diseased blasts, cells that are unable to reach the stage of maturity. As a result, these partially-developed cells can’t fulfill their actual purpose inside the body, generating serious impairments at different levels of the organism.

Functionless blasts multiply at abnormally high rates, eventually outnumbering healthy cells. In addition, diseased T-ALL cells block the production of normal blood cells, causing a decrease in the number of red blood cells, white blood cells and platelets. In present, T-cell acute lymphatic leukemia is known as the most common form of cancer among children. T-ALL predominantly affects children under the age of 15 and it is rarely seen in older children or young adults.

Medical scientists are currently trying to modify the leukemia drug Glivec so that it can also be administered to patients with T-ALL. Although Glivec is considered to be a reliable medication, it hasn’t been tested yet on patients diagnosed with T-ALL. However, oncologists believe that in future Glivec and other ABL1 inhibitors will be able to completely overcome T-ALL.



There are some diseases that occur without much of the fault of the sufferers. One of the most horrible diseases is Cancer and among Cancer if there is anything that is quite dangerous, it is the Leukemia. It is the Cancer of the blood or bone marrow. Its quite dangerous and difficult to cure.

There are two main types of Leukemia, the Acute and the Chronic. When the immature blood gets weight age in the body and it is increased more than the mature blood, it gets converted into Leukemia. In this type an immediate treatment is must as if the blood gets circulated in majority of the parts of body, it becomes difficult to handle the situation and that results into the blocking of bone marrow to produce healthy blood cells. So, the curing should be deadly faster. Also the lymphocytes Leukemia and myelogenous Leukemia are also the other types of this disease.

Leukemia Symptoms are difficult to find outer as it is totally internal process. If in any of the reports it is found to have the damage of bone marrow or even the lack of platelets can be the reason of this cancer. Other symptom can be the suppressing or dysfunctional behavior of White Cells in Blood without any reason. Leukemia prevents the immune system so if there are complains of frequent infections or even the tonsils, sores in mouth are felt, diarrhea, pneumonia or even the opportunistic infections are felt than there are bright chances of converting the diseases into Leukemia.

Causes of Leukemia

There are no visible reasons of Leukemia as such but still artificial ionizing radiation, different type of viruses that cause the blood platelets balancing problem and also the smoking or tobacco habit is the reason of this disease to occur to certain extent.

There are some of the people in whom the maternal-fatal transmission has become the reason for the Leukemia occurrence. Also some of the people are found to have the genetic predisposition as the reason of this disease to happen.

Treatment of Leukemia

The treatment is difficult yet not impossible as some of the medication treatment are required to get cured and beside this there are also the radiation therapy and bone marrow transplantation are the treatments of this diseases. But still nothing gives guarantee as the diagnosis has no outer symptoms and the stage in which the diseases are approached is also important.

So, have the best treatment and better curing of the diseases that is quite difficult to handle, Leukemia.