Leukemia severely affects a person’s immune system; the disease is characterized by low levels of leukocytes of white blood cells, which play an important role in the body’s defenses against disease. This disease can lead to other complications such as infections. However, for people who already have compromised immune systems, such as children and the elderly, developing leukemia can have some severe effects and complications. For children, the effects of leukemia can be very pronounced because battling the disease can take a toll on their fragile bodies.
Types of childhood leukemia
Just like in adult leukemia, children who develop the disease suffer either from large numbers of abnormal white blood cells or low levels of the white blood cells. Among cancers in children, leukemia accounts for about 25% of cancer cases. There are also different types of leukemia among children, categorized into two major categories: acute and chronic. Acute leukemia, or rapidly developing leukemia, is further divided into two types: Acute Lymphocytic Leukemia (ALL) and Acute Myelogenous Leukemia (AML). Acute leukemia accounts for 98% of all cases of childhood leukemia, with ALL being the most common. Chronic leukemia, or slowly developing leukemia, has only one type, which is Chronic Myelogenous Leukemia (CML), and it is very rare.
Symptoms and Treatment
The symptoms that a child with leukemia exhibits are similar to the symptoms that adults with the disease exhibit. Mostly, the symptoms are manifestations that the child’s immune system is compromised, including increased episodes of fever and other infections. Children with leukemia also suffer from anemia and the other blood abnormalities found in most leukemia cases. In addition, other symptoms include bruising and bleeding very easily, pain in the bones and the joints, swollen lymph nodes, malaise, and a poor appetite.
Usually, ALL is treated with chemotherapy. However, the dosage differs from what is given to adults. The medication that is given during this therapy is very potent, which is why for children, smaller dosages are given.
The effects of leukemia can be very hard to deal with, especially for children whose immune systems can be severely compromised by the disease. However, statistics show that children with this disease exhibit some of the highest remission rates, which means that with proper treatment, the chance of beating this disease is very high among children.
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Leukemia is cancer of the white blood cells. The bone marrow produces uncharacteristic white blood cells that do not function properly. These white blood cells eventually crowd out normal white blood cells, red blood cells, and platelets. One blood cell of a person suffering from leukemia goes awry and the body produces large numbers of this cell. In most cases the cell that goes awry is the white blood cell. There are four main types of leukemia. These vary on the type of white blood cell affected and the speed of progression. Acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML) are the four main types. Life expectancy of a patient suffering from leukemia varies from one type to another.
The medical fraternity’s understanding of and ability to treat leukemia has developed considerably in recent decades. In 1960, the 5-year survival rate for all types of leukemia was about 14%. It has now increased to about 50%. Children suffering from leukemia have a higher life expectancy rate, while people over the age of sixty have a comparatively lower life expectancy rate. The two main forms in which leukemia can be broadly termed are chronic and acute. Acute leukemia means that the disease grows rapidly and the usually life expectancy without treatment varies from a few weeks to a few months. Chronic leukemia, however, progresses gradually and with the appropriate cure, life expectancy can be up to 20 years or more after the onset of sickness.
Life expectancy of patients depends on the different factors such as health, age of the patient, severity of the disease, and treatment provided. While the life expectancy amongst ALL and AML is short due to its rapidly progressing nature, life expectancy amongst CLL and CML extend from three years to twenty years.
Over the years statistics have shown that life expectancy among people suffering from leukemia has grown considerably. This increase can be attributed to advanced studies and research. Innovation and invention of new and effective treatment procedures have also contributed to such an increase.
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AML, (acute myelogenous leukemia), is an aggressive cancer of the bone marrow and blood. It is the most common type of leukemia. AML is also known by the following names-acute myeloblastic leukemia, acute myeloid leukemia, acute granulocytic leukemia or acute nonlymphocytic leukemia. Blood cells are malformed and useless. The cells can accumulate in parts of the body.
Acute myelogenous leukemia statistics
o Rare in people under 40 years old
o More common in men than in women
o Average age is 65 years old
o 5-year survival rate
o under 65 years old-33%
o over 65 years old-4%
o 2007 it is predicted there will be 13,000 cases (majority will be adults)
The symptoms of acute myelogenous leukemia include abnormal blood counts, a general run-down, unwell feeling that never gets better, reoccurring infections, swollen lymph nodes, and bone/ joint pain. Symptoms are acute (comes on suddenly, and accelerates quickly) instead of chronic (mild symptoms that gradually worsen over years).
When the malformed cells collect around parts of the body, it can cause skin, lung, central nervous system, kidney, and even testicle problems. Initially, acute myelogenous leukemia may mimic other conditions. Blood tests identify the possibility of AML. The final diagnosis is usually made after a bone marrow test and sometimes by a spinal tap, also known as a lumbar (lower spine) puncture (LP).
There are several types treatments available, one or more will be used to treat a dignosis of AML.
Chemotherapy-strong drugs taken orally or intravenously that kills the cancer cells. Occasionally it’s injected directly into the spine. It is a systemic treatment because it travels throughout the whole body.
Radiation-high energy rays like X-rays kill the cancer cells
Bone marrow transplants-unhealthy cancer producing bone marrow is destroyed and replaced with matching bone marrow.
Immunotherapy-stimulates the immune system to destroy cancer cells or boosts natural defenses. It can be a made naturally or artificially.
Risk factors for AML
o Previous chemotherapy or radiation treatments
o Exposure to radiation and chemicals like benzene
o Genetic disorders like Downs Syndrome
o Smoking
o Blood disorders like myelodysplasia
People with risk factors should watch more closely for symptoms of AML because early treatment increases survival rate.


