Posts Tagged ‘Dopamine’



Cocaine is a very powerful stimulant that has significant affects on the brain and has an extremely high potential for drug addiction.

A highly addictive substance, Cocaine is a powerful stimulant derived from the leaves of the Coca plant native to South America. It is usually seen in a powdered form, as a powdered hydrochloride salt which is most commonly snorted, although it is also dissolved and injected.

Crack is another form of cocaine – this is a crystalline form of cocaine which has not been treated with acids to produce the familiar powdered form. Crack cocaine is heated and the vapors produced inhaled to produce an intense high, much as with the practice of “freebasing” which preceded the large scale production of Crack cocaine.

Cocaine is a stimulant. Like other stimulants, cocaine works on the central nervous system to stimulate the production of dopamine in the brain. It is dopamine which produces the “high” of the drug. This chemical is produced naturally by the brain in response to certain stimuli; but cocaine works by preventing the reuptake of dopamine, which intensifies the pleasure signals the chemical produces.

This disrupts normal brain function and produces a feeling of euphoria. However, habitual use of cocaine essentially rewires the brain, causing physical addiction. It actually can change the physical structure of the brain. In addition to producing addictive patterns of behavior, regular users of cocaine experience an increased tolerance to the drug so that larger and larger amounts are needed to produce the same sort of euphoric state. Along with this comes a much higher risk of severe physical and psychological effects.

How Does Cocaine Negatively Impact Health?

Cocaine abuse has a number of different negative effects on physical health. Cocaine causes the pupils to dilate, blood vessels to constrict and an increase in heart rate, blood pressure and body temperature. The drug can also cause digestive problems including nausea and abdominal pain, as well as headaches. Cocaine addicts may also have a tendency towards becoming malnourished, since the drug is a powerful appetite suppressant.


The negative health impacts of cocaine may vary with the method of ingestion. Snorting cocaine can cause nosebleeds, hoarseness, a runny nose and a loss of one’s sense of smell. Injecting cocaine exposes users to the risk of contracting HIV and other diseases if they share needles; allergic reactions are also not uncommon in cocaine-injecting users. Cocaine users can also run the risk of gangrene in the bowels due to reduced circulation. Heavy regular use of cocaine can cause anxiety, irritability and paranoid though patterns. Some cocaine users even experience psychotic episodes, sometimes developing into an actual paranoid psychosis.

Cocaine users are always at a higher risk of strokes and heart attacks, no matter how often they use cocaine or through what method the drug is ingested. There are those who have suddenly died from a cardiac arrest the very first time they have used the drug. Most cocaine related deaths are due to a sudden cardiac arrest upon taking the drug.



We all know that cocaine is physically and psychologically addictive but very few people know that it can kill you the first time you try it. Cocaine is made from the leaves of cocoa plant and when you use it, cocaine activates the release of chemical known as dopamine and prevents it from get reabsorbed into the body. This causes a state of euphoria, clarity and confidence. However, what people who use cocaine do not know is that you can cause damage to your heart and this damage will be permanent. In addition, cocaine use can cause heart attacks.

Cocaine, no matter how you use it, causes your heart rate to increase or it can cause irregular heart beats while constricting the blood vessels. When you get any one of these conditions, it can lead to serious problems which can even be fatal. Some problems that you can get due to increase heart rate or irregular heart beats are heart attacks, cardiac arrest, sudden death, damage to the heart muscle, inflammation of the heart lining, clots in the coronary arteries, fluids in the lungs or enlarged heart. While most people with heart disease can get these complications if they use cocaine; even those without heart disease are susceptible to them.

Cocaine usually affects the heart within 18 hours of use. However, it is quite possible for your heart to get affected immediately after use or up to four days later. You know that you have heart problems after using cocaine if you experience chest pain, have trouble breathing, feel anxious or dizzy, or experience palpitations or nausea.

If you have used cocaine and developed a heart problem, you should inform your doctor because the course of treatment will change accordingly. Many times patients are given benzodiazepines intravenously to combat the effects of cocaine and reduce the adverse effects on the heart.