Posts Tagged ‘Cause Of Anemia’



Those who suffer from Anemia either have a reduced number of red blood cells or a reduced amount of hemoglobin (the component of red blood cells that attaches to oxygen and transports it in the blood). Since there is less oxygen available to the cells in the body, Anemics have less energy to perform normal functions. The most common cause of Anemia is iron deficiency… iron is used to make hemoglobin. Most Anemics are on medication for life. We are interested in fixing the nutritional deficiencies underlying the condition to heal the ailment completely.

Iron is a trace mineral of vital importance to the body. Although there is only about a teaspoon of it in your body at any one time, it is essential in the formation of Hemoglobin, the red pigment of blood. There are two types of iron: Heme and Non-Heme. Now, Heme is more easily absorbed by the gastro-intestinal tract (10-30%) while Non-Heme is only about1-10% absorbed. Heme is available in the tissues of animals. That’s right, the more available source of iron is found in meats and dairy than in plants. But we suggest only obtaining your iron from vegetable sources. Why?

The interesting fact is that despite a less absorbable form of iron, vegetarians are no more likely to suffer from iron deficiency than non-vegetarians. Draper and Wheeler have stated there is no indication of increased prevalence of iron deficiency amongst vegetarians. Anderson found the iron status of long-term vegetarian women to be adequate, despite a high intake of fiber and phytate which INHIBITS the absorption of iron!

In fact, because iron can be stored in the body, too much iron can cause problems. Too much iron consumption leads to the production of free radicals (a molecule with an extra electron that will steal a negatively charged hydrogen electron from DNA, tissues, or organs which causes disease and aging). High levels of iron have also been found in association with heart disease and cancer. The buildup of iron in the tissues has been associated with a rare disease known as hemochromatosis, a hereditary disorder of iron metabolism that causes bronze skin pigmentation, cirrhosis of the liver, diabetes, and heart disorders. All of this leads us to the conclusion that despite animal foods, you should never get your iron from a supplement. First, the pill will not have all of the other organic nutrients (copper, manganese, molybdenum, Vitamin A, and the B complex) necessary to absorb the iron safely. Second, in pills, you will get something like ferrous oxide (oxidized iron: In other words, RUST).



Symptoms:

Weakness, fatigue, overall pallor, dizziness, pale lips and eyelids, depression, pale and brittle nails, and coldness of the extremities

Recommendations:

An all natural whole food supplement can be helpful. VITAFORCE(TM) is extremely abundant in organic iron and has extraordinary blood building properties. Iron is up to 16 times more absorbable if taken with Vitamin C and this is properly balanced naturally in VITAFORCE(TM). It is also extremely rich in all the other nutrients necessary for healthy blood. If you are anemic, then drink juices rich in chlorophyll. Chlorophyll is responsible for the green pigment in plants (called the “blood” of plants). Chlorophyll has almost the exact same chemical makeup of hemoglobin (less one iron molecule), both are responsible for carrying oxygen in the blood. Since the chemical makeup is almost identical, chlorophyll can quickly and easily be converted to hemoglobin. If the juices are rich in organic iron, then you have all the qualities for a blood transfusion. For example, the fresh organic juice of carrots, beets and beet greens dramatically increases the red blood cell count in the body. Dark leafy vegetables and especially They have extraordinary blood-building properties. Other foods that contain iron are asparagus, bananas, beets, dulse, kelp, whole grains (esp. millet & kamut), leafy greens, raisins, parsley, peas, plums, squash, prunes, purple grapes, broccoli, and yams.
Things to Avoid:

All inorganic supplemental forms of iron; none of the iron supplements use organic iron, so you cannot absorb any of it and it gets pissed away or lodged in your tissues where it can cause disease. Caffeine and tannins (in tea), and calcium inhibit iron absorption. So, avoid coffee and tea. Beer, candy bars, dairy products (milk, cheese, butter, ice cream, etc…), and soft drinks. Additives in these foods interfere with the absorption of iron. Foods containing oxalic acids inhibit the absorption of iron. Eat only in moderate amounts; almonds, cashews, chocolate, cocoa, soda, and most nuts and beans.
References:

1) James F. Balch, M.D, Phyllis A. Balch, C.N.C, “Prescription for Nutritional Healing,” (1997)

2) Anderson, B. et al. The iron and zinc status of long-term vegetarian women. Am J of Clin Nutr v.34 (6),(1981):p.1042-1048.3) Draper, A. & Wheeler, E. The diet and food choice of vegetarians in Greater London. Center of Human Nutrition, London.(1989)



It was shown that, even if it seems hard to believe, the initial signs of lupus may appear in the blood, a blood disorder can be the first sign that comes in patients having systemic lupus erythematosus.Systemic lupus erythematosus can show hematological symptoms like anemia, thrombocytopenia, low white blood cell counts and clotting disturbances. That is why, specialists in disorders of the blood can be of real help.

One of the most usual hematological abnormalities that can appear in persons having lupus is anemia. Anemia consists in a reduction in the number of red blood cells and it is recognized by some tests, such as, the hemoglobin concentration in blood, the hematocrit and the red blood cell count.It is known that anemia can have many causes, and in what concerns persons with lupus, anemia can appear because of a chronic inflammation, iron deficiency, prolonged uremia or hemolytic anemia. It is also known that fatigue, which is suffered by many patients having lupus can contribute to the apparition of anemia.

Prolonged uremia, which appears because of an impaired kidney function can lead to anemia. Anemia caused by prolonged uremia can be treated with androgens or erythropoietin, a recently developed hormone having role in the stimulation of red cell production. Sometimes, chronic uremia can determine the apparition of more severe forms of anemia, and that requires blood transfusions.

Prolonged inflammation, which is an important cause of anemia in patients that have lupus, hinders the production of red blood cells by the bone marrow. Because of this inflammation, iron, which is very important in the production of hemoglobin accumulates unused in the marrow tissue. The solution to restore normal red blood cell production is to ease the inflammatory condition.

Iron deficiency is another cause of anemia that can appear because of the blood loss from the body. Drugs that are used in the treatment of lupus can irritate the stomach and produce bleeding and from there results iron-deficient anemia. Iron deficient can become also women that have heavy or frequent menstrual periods.Anemic patients should take some tests for blood loss from the stomach or intestines. It is important to do that, because the source of bleeding must be found and treated.Iron deficient anemia can be corrected in a short time by taking iron tablets.

Hemolytic anemia is a condition that can appear in some people with lupus, usually due to antibodies directed against red blood cells. In this condition, auto-antibodies interact with the red blood cells, and the result is that the red blood cells are removed in the spleen or liver by scavenger cells.Usually, steroids like Prednisone are effective into treating this type of anemia, but there are cases of patients that do not respond to the treatment, and surgical removal of the spleen may be required. Also in severe cases, it is needed a blood transfusion.It is known that a deficiency of thrombocytes, which are tiny particles in the blood, essential for blood clotting causes thrombocytopenia. This leads to bleeding from the gums, nose, or intestines and excessive skin bruising. As some typical signs of thrombocytopenia, we can mention petechiae and pinpoint hemorrhages in the skin.In person with lupus, usually occurs immune thrombocytopenia. This appears because antibodies destroy the platelets, similarly with the destruction of the red blood cells in the autoimmune hemolytic anemia. As a treatment, we can mention steroids like Prednisone and in severe cases splenectomy may be needed.

It was discovered that patients that have lupus produce an antibody called the lupus anti-coagulant. It was seen that some patients with the lupus anti-coagulant tend to form clots abnormally condition called venous thrombosis. That is a paradox that science can’t explain yet.Sometimes, venous thrombosis can associate with pulmonary embolus, and particularly that situation requires treatment with anti-coagulant drugs such as heparin and Coumadin. Lupus anti-coagulant was also detected in cases of recurrent fetal loss, but it is not known if it causes the so-called habitual spontaneous abortion.

Patients with lupus can experience also some abnormalities , like granulocytopenia, which means there is a low granulocyte count, and lymphocytopenia- when there is a low number of lymphocytes. Usually, these abnormalities are harmless and without symptoms, but there can occur severe granulocytopenia, which is usually caused by a reaction to medication. In this case, there must be stopped the intake of the causative drug, and if there is an infection, treatment with antibiotics is required.

Nowadays, there is a great concern about the risk of getting AIDS by blood transfusions. It is good to know that there were developed tests for antibodies against the virus that causes AIDS, and all the blood donors are screened for such antibodies.Of course, the safest thing that can be done is to store your blood for later transfusion, but this is not always practical.It is also possible in some blood banks to designate a member of the family to donate blood for you, but it must be taken in consideration the possibility of blood incompatibility.



Approximately 1 out of 77 people in the united states of America suffer from Anemia. And as of 2004, an estimate of over 76 million people worldwide suffer from this ailment. What actually causes Anemia?

For an better overview of the causes, Anemia should be classified. The basic cause of anemia is either an increased loss or destruction of red blood cells or an impaired or decreased rate of production. An etiologic classification is based on the various conditions leading to either of these results.

Blood loss
Acute or chronic hemorrhage results in loss of plasma and all formed elements of the blood. After acute hemorrhage, the body replaces plasma within 1 to 3 days, maintaining blood volume. However, this results in a low concentration of rd blood cells, which are gradually replaced within 3 to 4 weeks. During this period there is usually a normocytic (normal size), normochromic (normal color) anemia, and there are sufficient iron sotries for hemoglobin synthesis.

In chronic blood loss, the actual number of red blood cells may be normal because of continual replacement. However, insufficient iron is available to form hemoglobin as quickly as it is lost. As a result, erythrocytes are usually small in size (microcytic and pale in color (hypochromic).

Excessive destruction
Excessive destruction or hemolysis of erythrocytes can occur from a variety of causes. One of the most common is a result of defect within the red blood cell (intracorpuscular) that shortens the life span of the cell so that production cannot keep pace with destruction. Sickle cell anemia and thalassemia, have decreased erythrocyte life spans because of a defect in hemoglobin synthesis.

Extra-corpular factors are those conditions that cause hemolysis in otherwise normal red blood cells. A classic example is erythroblastosis fetalis. Other causes can be toxic drugs, transfusion reactions, burns, poisonings (such as from lead), infections such as malaria, and splenic sequestration (hypersplenism).

Impaired or decreased production
Impaired or decreased production of red blood cells can occur as a result of either bone marrow failure or deficiency of essential nutrients. Bone marrow failure may be caused by
• Replacement of bone marrow by fibrosis or by neoplastic cells, such as in leukemia,
• Depression of marrow activity from irradiation, chemicals or drugs, or
• Interference with bone marrow activity from other systemic diseases, such as severe infection, chronic renal disease, widespread malignancy (without marrow infiltration), collage disease, or hypothyroidism.

The reason for various systemic disorders affecting erythrocyte production varies according to the condition. For example, in severe chronic infection there is evidence that depression of erythropoiesis is caused by a defect in the conversion of proteoporphyrin into hemoglobin. In addition, there is some degree of hemolysis, although the exact mechanism is not known.

The most common childhood anemia is a result of deficient iron supply, besides iron as an essential component of hemoglobin synthesis, red blood cell production is dependent on amino acids, vitamins B6, B9 and C, folic, copper and possibly cobalt. Chronic malnutrition results in anemia as a result of generalized protein. Mineral and vitamin deficiencies.

Pernicious anemia develops when the gastric mucosa fails to secrete sufficient amounts of intrinsic factor, which is essential for absorption of vitamin B12. This type of anemia is common in the elderly as a result of physiologically decreased gastric secretions. Deprived of vitamin B12, the bone marrow produces fewer but larger (macrocytic) red blood cells. The erythrocytes are usually immature and because of their extremely fragile cell membranes, are more rapidly destroyed during circulation.

Classification based on morphology
A second classification has been made that is based on the morphologic changes within the red blood cell. The major categories
1. normocytic
2. microcytic
3. macrocytic

In addition, each category may be subdivided according to the amount of hemoglobin in the cell, since hemoglobin gives the cell its characteristic red color, the usual classifications are
• normochromic
• microchromic

Classification based on Hb level
Stage I
• mild stage
• Hemoglobin level is 110-90g/l
• Erythrocyte count is 3.5-3.0×10^12/l

Stage II
• Moderate stage
• Hemoglobin level is 90-70g/l
• Erythrocyte count is 3.0-2.5×10^12/l

Stage III
• Severe stage
• Hemoglobin level is Laboratory criteria
Laboratory criteria of anemia in neonatal period are
• 0-14 days – Hemoglobin level is less than 145g/l
• 15-28days- Hemoglobin level is less than 120g/l



Dietary Deficiency: Is There a Connection?

What is anemia and what is the cause of anemia? There are various types of anemia, but in general, anemia is a blood disease. First, let me explain the function of the blood and how it works. The blood has several main functions: 1) to carry oxygen from our lungs to tissues in our body; 2) to carry waste products from the foods we eat; 3) to regulate the ability to clot; 4) to regulate our body temperature; 5) to regulate the amount of water and electrolytes in our body; and 6) to protect us from harmful organisms through antibodies and our white blood cells.

There are 3 kinds of blood cells: red blood cells, white blood cells and platelets. The red blood cells carry oxygen, white blood cells fight off infection, and platelets clot our blood. Aplastic anemia is when your body stops producing enough blood cells. If your body stops producing enough blood cells, then you are at risk of bleeding to death (hemopheliacs suffer from this) or you are at risk of getting diseases (AIDS patients are susceptible to this).

So what does diet have to do with any this? Well, although a healthy diet is the foundation of all things, Aplastic anemia, studies show that it can come from the following factors:

a) Radiation during chemotherapy

b) Exposure to toxic substances

c) Auto immune disorders

d) Certain medications

e) Pregnancy

Although the above factors seem to have nothing to do with diet, they are all indirectly related to poor dietary practices.

How Does Loss of Iron Increase Your Risk?

There are various types of anemia and therefore, various causes of anemia. Hemolytic anemia occurs when the red blood cells are destroyed before new ones can be reproduced. Doctors always first look for iron deficiency as a risk factor in patients when they are presented with anemia. There are various symptoms displayed when one has anemia, but more often than not, the most common symptom is fatigue.

The Function of Bone Marrow and Depletion of Cell Count

Another cause of anemia lies in the bone marrow. Bone marrow is responsible for reproducing new blood cells, but when someone has hemolytic anemia, the marrow cannot keep up with its production of new red blood cells with the rate of the premature destruction of the red blood cells. The depletion of cells jeopardizes the patient’s health.

Sickle Cell – What’s the Correlation?

Sickle cell anemia is caused by genetics. The cause of this type of anemia is inheritance. African Americans are often susceptible to sickle cell as they are in contracting tuberculosis (tb). Researchers don’t know why this is.

Normally our blood cells are round and they flow through the vessels of our body easily. Sickle cells are bean shaped, which doesn’t allow them to flow through the vessels. As a result, they get stuck in the vessel and these cells block blood from freely flowing to other parts of the body. The result is pain, serious infections and/or damage to the organs.

In sum, all types of anemia are serious. Although some types of anemia are rarer than others, such as Aplastic anemia, anemia is still a disease of the blood. Given the importance of the function of the blood, it is important that people schedule routine check ups with their physician, get plenty of iron, eat a healthy diet which includes plenty of fruit and vegetables, and exercise.



A complete blood count, which includes hemoglobin, hematocrit, white blood cell count, differential (what types of white blood cells are present), and platelet count, is one of the most common baseline tests ordered in an arthritis clinic. It is used for diagnosis and monitoring of medications and is also used to detect blood disorders such as anemia.

Understanding the cause of anemia in a patient with arthritis is important to providing appropriate treatment. For instance anemia can be due to abnormal destruction of red blood cells due to antibodies directed against the red blood cells. This phenomenon is occasionally seen in diseases like systemic lupus erythematosus (SLE). Low white blood cells counts and low platelet counts can also be seen in SLE.

Many types of inflammatory arthritis such as rheumatoid arthritis, SLE, etc., are associated with an anemia called the “anemia of chronic disease.” This type of anemia does not respond to iron. Red blood cells are normal size and normal color. The anemia is due to inflammation which “locks” the iron inside the bone marrow and prevents it from being used to make new red blood cells. The treatment for this anemia is better control of the arthritis.

Contrast that with the anemia from iron deficiency. This can be seen in patients treated with non-steroidal anti-inflammatory drugs (NSAIDS) who develop gastrointestinal bleeding. The anemia is caused by loss of blood and will respond to iron therapy. Red blood cells are small and pale.

Therapy with drugs such as methotrexate can lead to a deficiency of folate. This folate deficiency also causes an anemia. The anemia in this case is associated with large red blood cells. It is a sign that the patient needs to be treated with folic acid. Azathioprine is another drug used for arthritis that causes an anemia with large red blood cells.

Anemia should be investigated to determine whether the anemia is due to drug toxicity, complications of the arthritis, or some other cause. For example, a patient with large red blood cells may have a vitamin B12 deficiency accounting for their anemia.

Patients with anemia may complain of being fatigued or of feeling weak.

Patients with low platelet counts may be an increased risk for developing severe bleeding.

Patients with low white blood cell counts may be at increased risk for infections.

The presence of anemia or other blood abnormality will be an important determinant of the course of action needed to treat the patient and their arthritis.

Patient receiving arthritis medicines are at increased risk for developing different side effects. As a result they need to be monitored carefully.