Posts Tagged ‘B Cells’



Also known as a lymphoma, the lympho sarcoma is characterized as a fast multiplying of malignant lymphocytes. This takes place normally in the lymph nodes, liver, bones and spleen in most cats; although some may have development in the eyes and gastrointestinal tract and skin. The most common malignant cancer in cats, lymphoma in the feline species is growing.

In the young, this is found after the FeLV or feline leukemia virus shot is given, as well as with the feline immunodeficiency virus or FIV. This type of cancer in cats affects the spine, lymph nodes and the heart, aorta, esophagus, trachea and endocrine glands’ thymus (mediastinal lymphoma) in the thoracic cavity between the lungs.

In the gastrointestinal tract, lymphoma is more common in the elderly felines, where it can occur without the FeLV infection. The young normally have T-cell lymphoma where older cats are generally taken with B-cell lymphomas. T-cells are lymphocytes made in the thymus that tell the immune system to respond to infected or malignant cells. B-cells are lymphocytes that come from bone marrow.

Felines have worse and more severe symptoms than canines. Cancer in dogs may show a more visibly healthy dog, besides swollen nodes. But cats show severe symptoms that depend on the location of the cancer.

Symptoms for gastrointestinal cancer in cats show characteristics of diarrhea, no appetite and weight loss. The most reflected in fluid in the lungs and respiratory problems is the mediastinal lymphoma. When found in the kidney, symptoms of major thirst and urination are seen, and then kidney enlargement followed by failure.

Cancer in the heart leads to the heart no longer being able to pump blood to reduce the swelling of tissues, and the accumulation of fluid in the surrounding layers of the heart causes abnormal muscle reactions. Inflammation in the eye is also seen at times, and is known as ocular lymphoma.

Many forms of cancer are slow healing and can be present without imminent death, even without treatment of any kind. Aggressive cancers are normally given chemotherapeutic drugs, the same as in human cases. The best response is seen in the gastrointestinal cancers, rather that cancers found in more than one place. Cancer in cats is always dependent on past or present FeLV infection. Complete remission is very rare, because it is normally not the completed end to cancer.



Hodgkin’s lymphoma or Hodgkin’s disease is a rare for of cancer which is characterized by orderly growth of malignant cells of the lymphatic system. Described for the first time by Thomas Hodgkin in 1832, this disease primarily affects the lymph nodes and later spreads to other parts of the lymphatic system.

The most significant characteristic of Hodgkin’s lymphoma is presence of malignant B-cells with unique characteristics. These cells are called as Reed-Sternberg cells. Hodgkin’s lymphoma mainly occurs in individuals with depleted immune system and persons infected with viruses including HIV, Epstein-Barr virus and HTLV-I. Epidemiology of this disease is unique. The frequency of Hodgkin’s lymphoma is predominant in two separate age groups. These include individuals between 15-35 years of age and individuals above 55 years of age.

Hodgkin’s lymphoma is primarily classified into classical Hodgkin’s lymphoma (CHL), nodular sclerosis (NS), lymphocyte predominance (LP), mixed cellularity (MC), Lymphocyte depleted (LD) and nodular lymphocyte predominant Hodgkin’s lymphoma (NLPHL) depending on the Reed-Sternberg cell morphology. The most common symptom of Hodgkin’s disease is swelling in the lymph nodes of the neck and chest. Other noticeable symptoms include enlarged spleen, swollen liver, fever, excessive sweating, fatigue, abnormal weight loss and itchy skin. The disease could be medically diagnosed through microscopical examination of Reed-Sternberg cells during biopsy. Other diagnostic methods include physical examination, chest X-rays, blood cell counts, and CT scan and MRI scan of the lymphatic system, PET scanning, gallium scanning and bone marrow aspiration.

Hodgkin’s lymphoma is one of the first cancers to have been cured using radiation therapy. Other therapeutic approaches include chemotherapy, bone marrow and peripheral blood transplantation and immunotherapy. The common chemotherapeutic regimens followed for the treatment of Hodgkin’s lymphoma include ABVD (Adriamycin, bleomycin, vinblastine, dacarabzine), BEACOPP (bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine, prednisone), COPP/ABVD, MOPP (mechlorethamine, oncovin, procarbazine, prednisone) and Stanford V.