Luekemia is a cancer (malignant disease) of the blood or ‘bone marrow’, (soft tissue found in the hollow interior of the bone.) It is characterized by the uncontrolled accretion of blood cells, usually white blood cells. The word Luekemia means “white blood”, which was derived by luekemia patients’ high white blood count. An excessive amount of cells can interfere with other cells which causes a very harmful imbalance of blood count. There are four different categories of luekemia:
* Acute Lymphocytic Luekemia (ALL): This type of Luekemia is a rapidly progressing disease that is the most common type of Luekemia for children. However it does occur in adults, especially those over 65 years of age.
* Chronic Lymphocytic Luekemia (CLL): This type of luekemia (chronic) progresses more slowly than acute and most commonly affect those over 55 years of age. Once in a while will occur in a young adult but very rarely occurs in a child.
* Acute Myelogenous Luekemia (AML): More common to occur in an adult than a child.
* Chronic Myelogenous Luekemia (CML): Occurs mainly in adults and sometimes in children.
Some Statistics to Think About:
* To this day 218,659 people are living with luekemia in the United States.
* Luekemia affects about nine in 100,000 people each year.
* It is expected that 21,790 deaths in the United States are caused by Luekemia.
* Once diagnosed with luekemia, the five year survival rate is 42 percent.
* The estimated numbers of deaths caused by Luekemia in the US are about 30 percent higher for males than females.
* Adults are 10 times more likely to be diagnosed with luekemia than children, especially the elderly.
* About 515 children under the age of 14 are expected to die from Luekemia.
* Children under the age of 4 have a greater chance of developing luekemia than older children.
Symptoms:
Damage to the bone marrow will lead to a deficiency level of blood platelets which is important for blood clotting. This means people with luekemia may have problems with bruising, bleeding excessively, and petechiae. Petechiae is a small red or purple spot on the body caused by a minor hemorrhage. Other common symptoms for those who have Luekemia are:
* Weak immune system
* Anemia
* Fever, chills, and night sweats (flu like).
* Easily fatigued and weak.
* Swollen and bleeding gums.
* Frequent infection
* Bone and joint pain
* Dizziness
* Swollen tonsils
To find out more about the treatment process for leukemia, check out my informative site.
Archive for the ‘leukimia’ Category
The risk of any child developing leukemia is roughly about only 1 in 2000 with more or less 400 to 450 new cases a year in the United Kingdom only.
Cure rates impending seventy five percents can be achieved with combination chemotherapy, but this figure hide success rates that vary from ten to ninety percent with the different biological subtypes of the malady.
Nowadays, new insights into the underlying molecular biology of leukemia have changed our understanding of the disease. Not only are there a prospect of better treatment and the introduction of the new biologically based therapies, but, as the causes of disease are being unraveled, the possibility of prevention may not just be wishful thinking.
It has been recognized for a very long time that childhood leukemia is not one homogeneous disease. The main morphological division into acute lymphatic leukemia is supplemented by the identification of a range of subsets based on gene expression, antigens that delineate cell type or differentiation status, and chromosomal and molecular abnormalities.
There is now huge confirmation that chromosome trans location is very often the first event in infant twins with acute lymphocyte leukemia, the same breakpoints in the ML gene.
Further evidence that youth leukemia can originate before birth comes from scrutiny of neonatal blood spots or Guthrie cards. PR tests for specific fusion genes, designed for each patient, can detect as few as 1 in 20 leukemic cells in a blood spot. The presence of the same fusion gene sequence in a neonatal blood spot as is in the patient’s leukemic cells at diagnosis provides unequivocal evidence that leukemia, has been initiated prenatally, probably by creation of the fusion gene itself.
If this form of leukemia progress is actually correct, it means that for every child with acute lymphocyte leukemia diagnosed, there should be at least twenty healthy children who have a chromosome trans location, a functional leukemia fusion gene, and a covert per-leukemic clone generated in-uteri.
Cord blood bank can help cure this disease thanks to the stem cells in the cord blood. The cord blood is simply the blood that remains in the placenta and umbilical cord after a baby is born and can be used because it is so rich in stem cells.
The stem cells found in cord blood restore the function of the patient’s immune and blood producing systems, and is a powerful alternative to using bone marrow.
The most common treatment for leukemia is the chemotherapy.The therapy for children is produced by radiation and it is used only to treat leukemia in the central nervous system and the testicles.Unfortunately leukemia cannot be cured by surgery.A stem-cell transplant is the method which can be used.
Besides chemotherapy, immunotherapy can be successfully used.Therapeutic vaccines are used in human patients.Induction, consolidation and maintenance are the three phases of chemotherapy used in the treatment of acute lymphocytic leukemia and it develops over the course of a two to three year period.
In the case of chemotherapy induction and intensification are used for treatment of acute myelogenous leukemia.Chemotherapeutic drugs provided by the cerebrospinal fluid are received by patients throughout the course of treatment.In what concerns the cerebrospinal fluid chemotherapy discourage the spread of leukemia cells to the central nervous system.
Remission is the goal of induction.The body eliminates 99 percent of leukemia cells.The bone marrow is filled with normal hematopoietic stem cells.For most cases chemotherapy treatments last for about a month.For the patients with high-risk higher doses are used and for the acute myelogenous leukemia, different drugs are used.In both cases chemotherapy is continuously administered for ten consecutive days.
For inducing remission of acute promyelocytic leukemia are used retinoic acid and arsenic trioxide, after month of treatment patients survive induction.The person’s condition is critical until blood counts return to normal.Different treatments are required by chronic forms of the disease.The treatment is succesful by using the following medication:imatinib mesylate for patients with chronic myelogenousleukemia and cladribine and 2-deoxycoformycin which are both effective against hairy cell leukemia, a type of chronic lymphocytic leukemia.
Ten billion leukemia cells remain in the body after induction.The role of goals of consolidation referring to an intensification are to eliminate leukemia cells from locations such as the central nervous system and the testicles,where the cancer cells remains undetected by the immune system;the role of the cells being the one which reduces the number of leukemia cells remaining in the body.The last phase of treatment is the maintenance.Patients with low-risk and high-risk receive different drugs for leukemia in this case,but the drugs are used at lower doses than in the induction phase.
A relatively-new and complex treatment for leukemia is transplantation which consist in cells collected from cavities within bones where blood cells form or from the blood.For children with a poor chance of survival and for whom the treatment relapses the transplantation is used.Blood-forming stem cells are collected from patient or a donor with a nearly identical cell type.In this case the cells are frozen for storage.If the umbilical cord blood is available it can be use as a source of stem cells.
To kill all cancerous cells the patient follows a treatment with a very high dose of chemotherapy and radiation.All normal bone marrow cells are killed due to the does of chemotherapy and radiation.Then the bone marrow is repopulated by the stored stem cells which return to the body.To treat disease and also to maintain the immunity of the body immunotherapy is used.For the patients with leukemia interferon alfa which is an immune-system activator produced as a drug for bolstering the immune system of the body is successfully used.
The custom-made and duplicated antibody is produced in the laboratory and it is designed to interfere with malignant cells only which can also reduce the number of disease cells.Mylotarg is the monoclonal antibody has been approved for treatment of adults with refractory acute myelogenous leukemia.The improved technics and the science evolution have helped the people to find out different ways of destroying leukemia.
Nowadays, cancer is one of the most serious problems in medicine.Specialists try to discover new treatments. In clinics, the patients with cancer that start a new treatment are closely followed. Physicians determine the optimal dose which have the minimal side effects and offers the most numerous chances of survival. Because doctors make often adjustments, the treatment given to the patients does not always match with the treatment that studies found it to be the most effective. That’s why sometimes people receiving the treatment doesn’t feel very well, even if that treatment is supposed to save their life. If the patients have to get chemotherapy it is very important to respect the recommended doses and schedule, and it is also important to know the reasons why this rules are not respected.
There are a lot of cases when different types of cancer, like breast cancer or even the Non- Hodgkin’s lymphoma, are not correctly treated and it is not given the appropriate supportive therapy. It was proved that if those patients were treated appropriately and the treatment guidelines were followed, they would have a good chance of survival and possible cure.
The Non- Hodgkin’s lymphoma is a very aggressive type of cancer or the most common type of lymphoma. In lymphomas are affected the lymph glands and nodes that are anywhere in the body. So this kind of cancer can occur everywhere in the body. There is also a Hodgkin’s disease that can often occur in younger patients. The incidence of the Non- Hodgkin’s lymphoma is bigger in older patients, most frequently around age 60, but latest it can occur in younger people too. There is no explanation why this is one of the cancers that affects more and more individuals over the last 20 years.
Even if it is a very aggressive form of cancer it is very responsive in treatment and potentially curable cancer, which is a resemblance with the Hodgkin’s disease. An appropriate treatment can give the patients the chance to be cured and to live a normal life. This is justified for more than half of the patients.
So it was proved that the aggressive disease is more responsive to treatment which is a kind of a paradox which can be seen in many forms of rapidly growing cancers. The cells in this cancers are rapidly dividing, but they tend to be more responsive to treatment. The scientific explanation for this phenomenon is that the chemotherapy drugs are most active against rapidly growing cells.
The whole treatment in Non- Hodgkin’s lymphoma can last for about four to five months. If there is an early stage disease, the patient may get a shorter course of chemotherapy. This method must be combined with radiation therapy to the affected area. Because the cancerous cells may be anywhere in the body the biggest part of the patients with cancer needs to be treated systemically with chemotherapy. Chemotherapy is a combination of four or five drugs. The whole treatment program can run over a period of about four to five months.
Even if this form of cancer is a curable one, there are people with Non-Hodgkin’s lymphoma who being under-treated.
This under- treatment means a substantial dose reductions or treatment delays during their chemotherapy. This is one of the reasons why some of this patients presents side effects and they don’t get cured. It was proved in clinical trials that patients who receive the appropriate treatment do better than patients whose treatment is compromised by reducing the doses or not respecting the schedule. So the chances of long-term survival and cure are influenced by the way the treatments are being given.
There are some situations when reductions in doses of the treatment are unavoidable. This happens when there are older patients, or patients with a higher stage of disease, patients who aren’t able to care for themselves. in this circumstances the treatment have to be delayed too.
The best moment to give the appropriate treatment are the early stages of the disease. Preventative care is very important. Specifically treatment to boost low white blood cell counts caused by chemotherapy, are more likely to receive the dose on time and to receive fuller dose intensity than those patients who didn’t receive these agents. There many reasons,not only cancer, for which patients received these medications from the beginning.
Another cause of under- treatment is the situations when the patient doesn’t tolerate the chemotherapy the way it was expected to be. So it increases the concern about side effects. There are situations when the reduction in dose of the treatment is established from the very beginning, before the patient had received any kind of treatment. This is a conscious decision of the doctor who consult the patient and gets to the conclusion that he won’t tolerate the chemotherapy well. Other reductions in doses of the treatment occurs after starting therapy, because of the side effects. In this case reducing the dose is a strategy to reduce the side effects of treatment. This has negative results because it is very sure that to this patients the disease will come back months or years later.
Supportive care is very important. Older patients, patients who have more intensive symptoms from their disease or a higher stage of disease, need a type of a more aggressive supportive care. If they are supported in a right way it is also recommended to be treated the same as younger patients are. This increases their chances to be cured.When giving the supportive care it is important to analyze the risk factors. This are the patient’s age that can easily lead to more side effects or in the most cases determine the physician to reduce the doses or schedule of the treatment, even before starting it. Giving the right supportive care enables the patients at a higher risk to receive the full treatment.
Supportive care helps physicians and patients with cancer to control nausea, vomiting and infections that can result because of the low white blood cell count. These are one of the most common side effects of the toxicity of the chemotherapy. Supportive care includes treatments that can improve the blood counts and also reduce the risk of infection. So if the patients seem not to tolerate the chemotherapy well, it is recommended to use the supportive care and not to modify the doses and schedule in treatment. This way the patient will be allowed to go through the full program.
There are different kinds of treatments available and it is very important for the patients recently diagnosed Non- Hodgkin’s lymphoma to ask an oncologist about the side effects of those treatments and what can be done to diminish and to prevent them. It is very important for this patients to get the full treatment and to know that the target is to minimize side effects and to increase the effects of the appropriate treatment.
Leukemia occurs when the bone marrow produces abnormal white blood cells, which do not function properly and eventually crowd out normal white blood cells, red blood cells and platelets. It is basically a cancer of the white blood cells. Leukemia has increased at an alarming rate amongst people in the US. Many people are not even aware of the basic facts and symptoms of this life threatening disease. Often it is seen that lack of adequate information pertaining to leukemia leads to erratic and discriminative behavior against people suffering from this disease. Since people are scared of contracting the disease themselves, the most common question that is asked is with respect to its contagious nature by way of touch or social interaction.
When a person suffers from leukemia the family members or friends may have a number of queries relating to the disease. The person suffering would also want adequate and satisfactory answers to the various questions that come up in his mind. Normal persons looking for information on the disease may also ask questions. These frequently asked questions might relate to the causes for leukemia, the signs and symptoms of the illness and the preventive measures that can be taken to avoid it. Queries relating to the improved technologies used as a cure, survival rate with such treatment may also be asked. Since it is a life threatening disease, a person suffering from leukemia might also ask for the general life expectancy that is prescribed. Leukemia is divided into two main types i.e. acute and chronic. Since both types vary considerably, detailed information regarding the same may also be inquired.
Treatment for leukemia is a complicated procedure that is spread over a long period of time. Before undertaking such treatments, a person may want to know about the best possible treatment available, the cost of such treatment and the side effects that may possibly crop up. With the increasing use of the Internet, knowledge and information regarding leukemia can be easily obtained. Along with this a number of organizations also help people suffering from the disease and provide accurate information regarding the disease.
Cancer in any of its forms is known to the society as a condition of adults or elder persons; still it can occur at any age even during the care-free childhood period. Children diagnosed with cancer must rapidly grow up and learn hoe to face the illness as well as their parents that will have to be able to care for them.
The most common form of malignant tumors in children is the acute lymphocyte Leukemia and it is known to affect about 2500 pediatric patients every year. The acute forms of Leukemia develop rapidly and spread to the entire body in just a few months if left untreated. Knowing how to recognize the disease seems to be most important as Leukemia can lead to death in a very short time if not treated properly.
Leukemia develops inside the bone marrow and spreads to the lymph nodes, liver, spleen and nervous system. Cancerous marrow cells produce abnormal blood cells; insufficient or inefficient red blood cells lead to anemia, a low number of white blood cells leaves the body helpless to infections, and decreased number of platelets caused bruising and bleedings. General symptoms like headaches, weakness or vomiting also occur when the cancer reaches other main organs.
No way of prevention is known to us today as leukemia cannot be linked to any lifestyle factors. A good life expectation can only be reached if a doctor is seen immediately when symptoms occur and a proper treatment is quickly administered.
The most specific diagnose is the bone marrow biopsy when a small amount of marrow is extracted from the thighbone with a needle. The microscopic examination of the tissue can establish the presence of cancerous cells inside the bone marrow. Further analysis includes blood tests for searching changes in number and function of the three vital blood cells. In Leukemia a risen number of white cells are found together with a decreased number of red ones. Through the blood tests certain diagnose of the particular form of blood cancer can be established.
Cancer cells are dangerous as they divide very quickly and an efficient primer treatment with chemotherapy must stop their multiplication. More types of chemotherapeutics are required to kill all cancerous cells as Leukemia is known to spread very rapidly throughout the whole body. The drug therapy is a long-lasting process and can produce several side-effects such as hair loss, infections, tiredness, nausea, anorexia and vomiting.
New ways of therapy are searched that should only affect the cancerous cells unlike conventional drugs. The stem cells transplantation targeting to replace the lost marrow working cellularity seems to give hopeful results.
Blood cancer can reoccur and therefore a treatment with stem cells can give more effective results. If Leukemia cannot be treated, doctors try ways of making the patient’s life with cancer easier by relieving the symptoms. About 85% of the children that have survived 5 years without cancer reoccurring are considered to have been cured.
The therapy of chronic myeloid leukemia with Gleevec (Imatinib mesylate) began to be used in patients in 2001 and seemed to be real success. Since that time, a clinical study revealed the efficiency of Gleevec in other cancer types as well such as in hypereosinophilic syndrome, another blood cancer.
Gleevec is a targeted drug on abnormal cells of the body and doesn’t attack healthy cells like other chemotherapeutics. Gleevec is efficient against a protein called BCR-ABL from the class of enzymes known as thyrosine kinases which is responsible for the excessive multiplication of mature and immature white blood cells in the chronic myeloid Leukemia.
Most cancer forms are caused by genetic mistakes leading to the production of malfunctioning proteins that send a wrong message to the cells. When the abnormal enzymes are inhibited by chemotherapy, the cancer progression is also stopped. Scientists work to find other similar drugs like Gleevec that have the capacity to inhibit dysfunctional enzymes such as tyrosine kinases.
In normal conditions, tyrosine kinases send different signals to the cells stimulating them to perform different actions. Abnormal enzymes send modified messages to the cells allowing them to multiply particular cells in an abnormal rate and cancer appears. 4500 new cases of CML are discovered every year and Gleevec was firstly used on this type of cancer. Chronic myeloid leukemia is caused by a translocated, genetically modified chromosome called Philadelphia causing the occurrence of abnormal tyrosine kinases. This is the primer cause of leukemic cells occurrence in the bone marrow and blood.
Many of the chemotherapeutics used to treat leukemia have negative effects on other healthy tissues as well like skin, bone marrow, and gastrointestinal track or hair follicles, and causes injuries to organs like heart, kidneys or lungs. Gleevec is targeted on mutant protein and enzyme cells and only destructs this type of genetically modified tissues. Gleevec also has its side-effects such as nausea, vomiting, skin rashes or fluid retention due to its toxicity but they are far less dangerous for the human body than other drugs.
The drug therapy using Gleevec proved far more efficient than earlier methods and showed real more improvements for the CML patients. It impressively reduces the number of white blood cells and the number of leukemic cells inside the bone marrow. Gleevec can also be used on persons not responding to the Interferon therapy or the ones that proved intolerant to it.
The administration of Gleevec is easier as well as it is available as a pill not as injections like most of the other drugs. This aspect makes the self-administration possible and spares patients from staying in the hospital for long periods of time.
First occurring signs in the development of acute forms of leukemia are bruising and bleedings caused by the decreased number of platelets, fatigue and pales due to the anemia caused by insufficient red blood cells, reoccurring infections and late healing due to abnormal number and function of white blood cells. These symptoms are however not specific for the Leukemia condition and for a precise diagnose further testing is required such as analysis of blood and bone marrow.
A certain cause of Leukemia is not yet known as it can affect persons of all ages and both sexes. A link however between leukemia and benzene prolonged exposure or high doses of radiations could be established. But most cases cannot be rationally explained.
The main target of the Leukemia treatment is to annihilate all existing abnormal cells in blood and bone marrow. A complete remission means no left trace of cancerous modifications. Some of the treated cases show a reoccurrence of the disease with other signs and symptoms. In acute leukemia forms, after five years of remission after treatment the patient can be qualified as cured and the condition rarely reoccurs.
In the last 25 years the percent of surviving subjects has increased due to new therapy ways. The overall five-year survival rate is 44% today, with significant progresses compared to the 1960′s rate of only 14%. The rate of survival differs by age, type of leukemia and previous health status. In the case of acute lymphocytic Leukemia the rate is 58%, in the chronic form it reaches 71%, in acute myelogenous Leukemia the rate is 14% and the chronic form reaches 32% five-year survival.
In present there are about 144000 patients suffering from Leukemia in the USA. The rate of survival in children suffering from acute lymphocytic leukemia is 81% if detected in early stage. For children diagnosed with acute myelogenic Leukemia the rate is 43%.
In 2001 about 12500 male subjects are known to have died from Leukemia and a lower number of 9500 women, in the United States. The estimated number of chronic lymphocytic deaths yet to occur is 4600 and 1400 from acute lymphocytic forms. Acute myelogenous Leukemia is expected to produce 7200 deaths and chronic myelogenous Leukemia about 2300 deaths. Other forms of leukemia will be responsible for approximately 600 death cases.
For males under 40 and for women less than 20 leukemia represents the main cause of death. The estimated rate of deaths in males of Leukemia is 25% higher than in females. The percent of death cases in children has decreased in the last 30 years but the rate still remains high.
No human is alike another on this planet. Because of the this the way that the disease leukemia affects people is also very different. Some patients may experience severe or acute symptoms, while in others the action of the symptoms may be so mild that a long time passes till the disease is actually found and diagnosed; this can go on for years or even decades. All of us know that leukemia is the worst cancer that exist in this days and that affects people. Properly diagnosing this disorder can prove quite tricky some times, the fact being that many of its symptoms do resemble the symptoms of other very common and not life threatening illnesses.
Some of the most usual symptoms found in leukemia patients are fever, chills or other symptoms that resemble the ones of flu; weakness or fatigue may also appear in patients. Because of the heavy tole that the disease has on the body the patient may experience loss of appetite and normally after this, the weight might severely drop. Severe sweating may also be present, especially during sleep, at night time. Swollen or bleeding gums may be some of that symptoms to show us that the disease is getting serious and taking a heavy tole on the patient. Because of the lack of oxygen and nutrients that the body is receiving, bone or joint pain may also make them selves felt. Because the fact that the brain is also affected, headache, paralysis, seizures may sometimes trouble the patient with different intensities. In men the case might also include the swelling of the testicles, witch is a very nasty thing. Skin symptoms may also appear like rashes, loss of hair.
To be sure of the diagnose he makes, the doctor will most certainly run a wide variety of tests to rule out any other disease that is suspected to cause trouble to the patient. As long with physical test the doctor will also take blood samples to be more shore of the diagnose that he makes. High white blood cell count would most certainly indicate an over production of the bone marrow, but this does not necessarily mean the person has leukemia. A further more thorough test will actually include the extraction of some bone marrow for a bone marrow biopsy. If in this case a problem is discovered than the patient is in for some bed news. Still these test are extremely painful, often making patients to think again about taking them.









